Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression.

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Tác giả: David Bending, Thomas N Burn, David Chisanga, Leonie A Cluse, Weiguo Cui, Sarah S Gabriel, Catarina Gago da Graça, Ricky W Johnstone, Axel Kallies, Sining Li, Laura K Mackay, Dane M Newman, Minh-Hanh T Nguyen, Simone L Park, Annika Poch, Lisa Rausch, Jan Schröder, Justine Seow, Amania A Sheikh, Jian Shen, Wei Shi, Jayendra Singh, Chun-Hsi Su, Carlson Tsui, Daniel T Utzschneider, Ajithkumar Vasanthakumar, Bianca Von Scheidt, Lifen Wen, Yuqi Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Science immunology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 177773

Stem-like T cells are attractive immunotherapeutic targets in patients with cancer given their ability to proliferate and differentiate into effector progeny. Thus, identifying T cells with enhanced stemness and understanding their developmental requirements are of broad clinical and therapeutic interest. Here, we demonstrate that during acute infection, the transcriptional regulator inhibitor of DNA binding 3 (ID3) identifies stem-like T cells that are uniquely adapted to generate precursors of exhausted T (Tpex) cells in response to chronic infection or cancer. Expression of ID3 itself enables Tpex cells to sustain T cell responses in chronic infection or cancer, whereas loss of ID3 results in impaired maintenance of CD8 T cell immunity. Furthermore, we demonstrate that interleukin-1 (IL-1) family members, including IL-36β and IL-18, promote the generation of ID3
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