OBJECTIVES: The aim of the study was to assess the mechanical thrombectomy (MT) and catheter-directed thrombolysis (CDT) use in patients with deep vein thrombosis (DVT) in tertiary care. METHODS: We conducted a single-center retrospective cohort study. A tertiary hospital database from January 2022 to December 2023 was analyzed. All records of patients referred for DVT were extracted. The collected data included general patient information, medical history, results of physical examination, duplex ultrasound, and laboratory analyses. We assessed indications and contraindications for MT and CDT considering possible benefits and risks. We have identified patients who could be eligible for this technique. RESULTS: A total of 2427 patients with DVT were referred to hospital from January 2022 to December 2023. Among them, 961 patients (39.6%) had no indications for hospital admission or refused it and were recommended to receive anticoagulation on an outpatient basis, and 1466 patients (60.4%) were admitted to the hospital. Among the hospitalized patients, 1277 had a proximal DVT and 189 had a distal DVT. The number of patients with iliofemoral DVT was 451 (18.6%). We found only 82 cases (3.4%) that could be potentially eligible for endovascular thrombectomy considering all possible indications and contraindications. Two attempts and 14 successful procedures were conducted during the period of the study. CONCLUSIONS: The number of patients with DVT who could be eligible for MT and CDT in a tertiary hospital is low.