Retinal pharmacodynamic and pharmacokinetic profile of cannabidiol in an in vivo model of retinal excitotoxicity.

• Tác giả: Claudio Bucolo, Federica Conti, Michele D'Amico, Serena Di Martino, Filippo Drago, Martin Kuchar, Francesca Lazzara, Chiara Bianca Maria Platania, Vincenzo Micale, Rosario Pignatello, Giovanni Luca Romano, Settimio Rossi, Angelo Spadaro, Dimitris Spyridakos, Kyriaki Thermos, Elide Zingale
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.2 Programming for specific types of computers, for specific operating systems, for specific user interfaces
• Thông tin xuất bản: Netherlands : European journal of pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 177926

Tóm tắt

Cannabidiol (CBD) is one of the principal constituents of Cannabis Sativa with no psychoactive properties. CBD is a promising neuroprotective compound bearing anti-inflammatory and antioxidant properties. However, considering its low solubility, CBD delivery to the retina represents an unresolved issue. The first aim was to investigate the potential neuroprotective effects of CBD in an in vivo model of retinal excitotoxicity induced by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA). Rats underwent intravitreal co-injection of AMPA (42 nmol) and CBD (10