The C2 domain augments Ras GTPase-activating protein catalytic activity.

• Tác giả: Titus J Boggon, Di Chen, Zachary T Freeman, Elizabeth Hughes, Philip D King, Nathaniel L Lartey, Maxum E Paul, Thomas L Saunders, Amy L Stiegler, Kimberly J Vish
• Ngôn ngữ: eng
• Ký hiệu phân loại: 613.718 Stretching exercises, and exercises for muscles of specific parts of body
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 178060

Tóm tắt

 Regulation of Ras GTPases by GTPase-activating proteins (GAPs) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical GAP domain, and in RasGAP (p120GAP, p120RasGAP