Broad-spectrum tolerance to disinfectant-mediated bacterial killing due to mutation of the PheS aminoacyl tRNA synthetase.

• Tác giả: Miaomiao Chen, Runbo Cui, Karl Drlica, Shouqiang Hong, Yuzhi Hong, Jiahao Li, Zihan Nie, Jianjun Niu, Dai Wang, Yunxin Xue, Qiong Yang, Yanghui Ye, Xue Zhang, Xilin Zhao, Weiwei Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0885 Animal husbandry
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 178084

Tóm tắt

Disinfectants are essential tools for controlling infectious diseases and maintaining sterile conditions in many medical and food-industry settings. Recent work revealed that a deficiency in the carbohydrate phosphotransferase system (PTS) confers pan-tolerance to killing by diverse disinfectant types through its interaction with the cAMP-CRP regulatory network. The present work characterized a pan-tolerance mutant obtained by enrichment using phenol as a lethal probe and an