γδ T cell characterisation in the long term after haematopoietic stem cell transplantation and its impact on CMV control and cGVHD severity.

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Tác giả: Faisal Alagrafi, Lucas Cm Arruda, Ahmed Gaballa, Thomas Poiret, Olle Ringden, Martin Solders, Arwen Stikvoort, Michael Uhlin

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: Australia : Clinical & translational immunology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 178171

OBJECTIVES: The clinical outcome after allogeneic haematopoietic stem cell transplantation (aHCT) relies greatly on the efficient recovery of T cells. Several studies have investigated the short-term γδ T cell reconstitution and their role in clinical outcomes following haematopoietic stem cell transplantation. Nevertheless, their long-term characteristics and impact have remained largely unknown. METHODS: We analysed γδ T cells from 20 recipient/donor pairs at phenotypic, clonotypic and functional levels to assess their reconstitution ≥ 8 years (median 18 years) post-transplantation using high-parameter flow cytometry and next-generation sequencing of the TCR γ-chain. RESULTS: γδ T cells displayed comparable phenotypic characteristics between recipients and matching donors. The Vδ2 CONCLUSION: Overall, γδ T cells reconstitute with a normalised repertoire, high functional capacity and sustained CMV control ability. An increased proportion of activated Vδ1
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