Spatial propagation of temperate phages within and among biofilms.

• Tác giả: Carey D Nadell, James B Winans, Lanying Zeng
• Ngôn ngữ: eng
• Ký hiệu phân loại: 620.11215 Engineering mechanics and materials
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 178360
• Chủ đề: 1. Spatial; 2. Propagation; 3. Of

Tóm tắt

Bacteria form groups composed of cells and a secreted polymeric matrix that controls their spatial organization. These groups-termed biofilms-can act as refuges from environmental disturbances and from biotic threats, including phages. Despite the ubiquity of temperate phages and bacterial biofilms, live propagation of temperate phages within biofilms has not been characterized on cellular spatial scales. Here, we leverage several approaches to track temperate phages and distinguish between lytic and lysogenic host infections. We determine that lysogeny within