Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer.

• Tác giả: Atef Ali, Emmanuel S Antonarakis, Gerhardt Attard, Himisha Beltran, Hannah E Bergom, Ella Boytim, Frank Claessens, Eva Corey, Scott M Dehm, Wout Devlies, Colleen Forster, R Stephanie Huang, Justin Hwang, Mazlina Ismail, Steven Joniau, John T Lafin, Joshua M Lang, Simon Linder, Braedan M McCluskey, Sarah A Munro, Paari Murugan, Peter S Nelson, Samuel P Pitzen, Yinjie Qiu, Amber N Rudenick, Conner J Sessions, Douglas Strand, Yuzhuo Wang, Weijie Zhang, Wilbert Zwart
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.523 Cooperative information services
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 178689

Tóm tắt

Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR-dependent luminal epithelial cell identity. Tumors progress during therapy to castration-resistant prostate cancer (CRPC) by restoring AR signaling and maintaining luminal identity or by converting through lineage plasticity to a neuroendocrine (NE) identity or double-negative CRPC (DNPC) lacking luminal or NE identities. Here, we show that DNPC cells express genes defining basal, club, and hillock epithelial cells from benign prostate. We identified KLF5 as a regulator of genes defining this mixed basal, club, and hillock cell identity in DNPC models. KLF5-mediated upregulation of