Development of a Second-Generation,

• Tác giả: Alison D Axtman, Frances M Bashore, Rafael M Couñago, Tammy M Havener, Stefanie Howell, Haoxi Li, Sophia M Min, Konstantin I Popov, Jeffery L Smith
• Ngôn ngữ: eng
• Ký hiệu phân loại: 787.86 *Vihuelas
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 179093

Tóm tắt

We optimized our highly potent and cell-active chemical probe for phosphatidylinositol-3-phosphate 5-kinase (PIKfyve), SGC-PIKFYVE-1, resulting in compounds with improved potency and demonstrated