To survive, animals must rapidly learn to avoid aversive outcomes by predicting threats and taking preemptive actions to avoid them. Often, this involves identifying locations that are safe in the context of specific, impending threats and remaining in those locations until the threat passes. Thus, animals quickly learn how threat-predicting cues alter the implications of entering or leaving a safe location. The prelimbic subregion (PL) of the medial prefrontal cortex (mPFC) integrates learned associations to influence threat avoidance strategies.