Bioactive Zn-V-Si-Ca Glass Nanoparticle Hydrogel Microneedles with Antimicrobial and Antioxidant Properties for Bone Regeneration in Diabetic Periodontitis.

• Tác giả: Kai Jiao, Ling Li, Yuxuan Ma, Zhao Mu, Lina Niu, Wen Niu, Wen Qin, Zixuan Qin, Franklin R Tay, Chenyu Wang, Tao Ye
• Ngôn ngữ: eng
• Ký hiệu phân loại: 328.22 Initiative
• Thông tin xuất bản: United States : ACS nano , 2025
• Bộ sưu tập: NCBI
• ID: 179537

Tóm tắt

Periodontitis is a chronic inflammatory condition affecting the periodontal tissue. This condition worsens in diabetic patients due to oxidative stress and inflammation. Herein, we investigated a treatment using bioactive Zn-V-Si-Ca glass nanoparticle hydrogel microneedles. The microneedles contain bioactive glass nanoparticles codoped with zinc and vanadium ions. They also include gallic acid and oxidized methacrylated hyaluronic acid. These microneedles address bacterial dysbiosis and oxidative stress in diabetic periodontitis. They provide antibacterial and antioxidant effects. The microneedles deliver therapeutic agents directly into the gingival tissue. This enhances drug retention and absorption by penetrating the mucosal barrier.