STUDY DESIGN: Global cross-sectional survey. OBJECTIVE: To validate the hierarchical nature of the AO Spine Upper Cervical Spine Injury Classification (UCIC) across AO geographical regions/practice experience. SUMMARY OF BACKGROUND DATA: In order to create a universally validated scheme with prognostic value, AO Spine established an upper cervical spine injury classification involving three elements: injury morphology (region: I - occipital condyle and craniocervical junction
II - C1 ring and C1-2 joint
III - C2 and C2-3 joint), and (subtype: A - isolated bony injury
B - bony/ligamentous injury
C - displaced/translational injury), neurologic status (N0 - intact
N1 - transient deficit
N2 - radiculopathy
N3 - incomplete spinal cord injury (SCI)
N4 - complete SCI, and NX - unable to examine), and case-specific modifiers (M1 - injuries at risk of nonunion
M2 - injuries at risk of instability
M3 - patient specific factors
M4 - vascular injury). METHODS: 151 AO Spine members (orthopaedic and neurosurgery) were surveyed globally regarding the severity (zero - low severity to 100 - high severity) of each UCIC variable. Primary outcomes were differences in perceived injury severity score (ISS) over various geographic/practice settings, level of experience, and subspecialty. RESULTS: 148 responses were received. There was an increase in median perceived severity as each anatomic region (I-III) progressed from types A to B to C. Neurologic status progressed similarly, except N1 and N2 were perceived similarly. Modifier M2 was perceived more severely than M3. There were no differences in ISS amongst levels of surgeon experience. There were small geographic differences with respondents from North and Central and South America perceiving types IC (P=0.003), IIB (P=0.003), and IIIB (P=0.003) somewhat more severely than other regions. Neurosurgeons perceived types IB (P=0.002) and IIIB (P=0.026) as more severe than orthopaedic spine surgeons. CONCLUSIONS: The AO Spine UCIC has overall excellent hierarchical progression in subtype ISS. These findings are consistent across geographic regions, spine subspecialty training and experience levels.