There is growing evidence for hormetic stimulation of Microcystis aeruginosa, a harmful algal bloom (HAB)-forming cyanobacterium, by subtoxic contaminant concentrations. Hence, the first meta-analysis of approximately 4000 dose responses was conducted to evaluate the underlying biological mechanisms, identify variation determinants, and reveal potential implications for algaecides effectiveness. Approximately 30 chemical contaminants caused significant stimulation (95% CI: 72-153%), which persisted in mixtures, regardless the level of mixture complexity. Stimulation by subtoxic antibiotic contamination occurred in the presence or absence of algaecides, highlighting the potential of chemical contamination to lower algaecide efficiency to control the cyanobacterium. The significant stimulation spanned a wide range of contaminant concentrations, from ≤0.0001 to 200 mg L