Atherosclerosis is an age-related disease affecting the tunica intima of large and medium-sized arteries. Its occurrence in extracranial head and neck arteries is rare, with only five cases reported. This study is aimed at reporting the sixth case of atherosclerosis of the angular artery, a branch of the facial artery, in an elderly male patient with a history of hypertension. Morphological characterization using special stains and a literature review are included. Clinically, a painless, nodular lesion measuring 1.2 cm was observed at the right labial commissure. The lesion was excised, and atherosclerosis of the angular artery was diagnosed. After 6 months, there was no recurrence or other arterial issues. Despite its rarity in the oral and maxillofacial region, dental clinicians must be aware of this condition and its clinical manifestations, especially in elderly patients with chronic systemic diseases, to establish an accurate diagnosis.