AIMS: Over time, clinical outcome after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents (DES) has improved. While most patients survive for many years after PCI, data on potential sex differences in age-specific 10-year mortality risk in all-comer patients are scarce. This study aimed to examine the sex- and age-specific 10-year mortality risk after PCI with new-generation DES. METHODS AND RESULTS: This investigator-driven study assessed women and men, enrolled in our centre in two large-scale all-comer PCI trials (TWENTE and DUTCH PEERS
CONCLUSION: PCI patients of both sexes showed higher 10-year age-specific mortality risks than the general population with a more pronounced difference observed in women. There was no sex difference in underlying causes of death. Furthermore, both women and men who died had higher cardiovascular risk profiles than those who survived.