Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists.

• Tác giả: Eric P Arnold, Mark W Bundesmann, Gary M Chinigo, Kimberly Crouse, Kathleen A Farley, Andrew Flick, Richard K Frisbie, Brian S Gerstenberger, Neelu Kaila, Daniel Lamb, Wei Li, Vincent M Lombardo, James J Mousseau, Nootaree Niljianskul, Philippe Nuhant, Mathieu Rappas, Mark E Schnute, Atli Thorarensen, John I Trujillo, Ray Unwalla, Michael L Vazquez
• Ngôn ngữ: eng
• Ký hiệu phân loại: 021.28 Informational role
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 180390

Tóm tắt

CCR6 is a chemokine receptor that mediates the migration of pathogenic inflammatory leukocytes to sites of inflammation in response to its ligand, CCL20. Herein we report the design of a potent CCR6 antagonist capable of inhibiting the chemotactic migration of CCR6