2-Aminopyridine nucleobases enable DNA invasion by peptide nucleic acid clamps under physiological conditions.

• Tác giả: Eriks Rozners, Brandon R Tessier
• Ngôn ngữ: eng
• Ký hiệu phân loại: 324.274703 Political parties
• Thông tin xuất bản: England : Chemical communications (Cambridge, England) , 2025
• Bộ sưu tập: NCBI
• ID: 180404

Tóm tắt

Peptide nucleic acid (PNA) clamps modified with 2-aminopyridine (M) nucleobase invaded double-stranded DNA under physiological salt conditions. In contrast, PNAs carrying common nucleobases could not fully invade DNA under these conditions. M-modified PNAs may overcome the problematic requirement for low salt concentration, a long-standing DNA invasion problem.