High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.

• Tác giả: Isabel N Alcazar, Gabriele Allies, Massar Alsamraae, Fang Brister, Ling Cai, Robert B Cameron, Brianna K Chang, Maia G Clare, Hannah E Crentsil, Ralph J DeBerardinis, Quyen N Do, Bret M Evers, Brandon Faubert, Wen Gu, Nia G Hammond, Christopher T Hensley, Mayher Kaur, Akash Kaushik, Kemp H Kernstine, Joachim Klode, Katarzyna Kurylowicz, Andrea Kutritz, Hong Li, Joseph D Marcuccilli, Luiza Martins Nascentes Melo, Thomas P Mathews, Phyllis McDaniel, John D Minna, Sean J Morrison, Dwight Oliver, Panayotis Pachnis, Peiran Quan, Vijayashree Ramesh, Aparna D Rao, Thomas J Rogers, Ashley Solmonson, Jessica Sudderth, Alpaslan Tasdogan, Jessalyn M Ubellacker, John Waters, Jian Xu, Xiaohong Xu, Chendong Yang, Lauren G Zacharias, Qin Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 230.071 Education in Christianity, in Christian theology
• Thông tin xuất bản: United States : Cancer discovery , 2025
• Bộ sưu tập: NCBI
• ID: 180438

Tóm tắt

Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis of human NSCLC cells in mice.