OBJECTIVES: The inclusion of social drivers of health (SDOH) into predictive algorithms of health outcomes has potential for improving algorithm interpretation, performance, generalizability, and transportability. However, there are limitations in the availability, understanding, and quality of SDOH variables, as well as a lack of guidance on how to incorporate them into algorithms when appropriate to do so. As such, few published algorithms include SDOH, and there is substantial methodological variability among those that do. We argue that practitioners should consider the use of social indices and factors-a class of area-level measurements-given their accessibility, transparency, and quality. RESULTS: We illustrate the process of using such indices in predictive algorithms, which includes the selection of appropriate indices for the outcome, measurement time, and geographic level, in a demonstrative example with the Kidney Failure Risk Equation. DISCUSSION: Identifying settings where incorporating SDOH may be beneficial and incorporating them rigorously can help validate algorithms and assess generalizability.