The SARAH trial: more evidence on the role of neurohormonal blockers in prevention of anthracycline-induced cardiotoxicity.

• Tác giả: Albulena Mecinaj, Peder L Myhre, Doan T M Ngo, Aaron L Sverdlov, Victoria Vinje-Jakobsen
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.5074 *Greece
• Thông tin xuất bản: United States : Heart failure reviews , 2025
• Bộ sưu tập: NCBI
• ID: 180965

Tóm tắt

This mini-review highlights the results of the SARAH trial, which evaluated the efficacy of sacubitril/valsartan in preventing subclinical cardiac dysfunction in patients undergoing anthracycline-based chemotherapy. The trial demonstrated a significant reduction in GLS decline in the treatment group compared to placebo. The findings are discussed in context with other trials investigating neurohormonal blockade for the prevention of cancer therapy-related cardiac dysfunction.