Catalytic Enantioconvergent Alkylation Reactions That Construct Chiral Quaternary Carbon Centers and Tune C(sp3)-C(sp2) Bond Rotation.

• Tác giả: Keisuke Kobayashi, Taichi Ohshiro, Muhammad Sohail, Fujie Tanaka, Hiroshi Tomoda
• Ngôn ngữ: eng
• Ký hiệu phân loại: 296.09015 Judaism
• Thông tin xuất bản: Germany : Chemistry (Weinheim an der Bergstrasse, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 181052

Tóm tắt

In molecules with central chiral centers functionalized with aryl groups, the rotation of the single bond between the aryl group and the central chiral center may be hindered. Enantioconvergent alkylation reactions of racemic diastereomers to construct all-carbon quaternary stereocenters resulting in easing of the rotation around the axes are described. We demonstrated that the rotation of the bond between a central chiral carbon center and a dihydrobenzofuranone can be tuned by selection of either a tertiary carbon bearing a hydrogen or a quaternary carbon at the central chiral center. The products have the benefits of a central chiral center and a flexibly rotatable bond, which can facilitate interactions with other molecules.