This study was conducted to demonstrate the impact of a software-based cost awareness intervention on the reduction of cost of surgical disposables used in thoracic, gynecological, colorectal and plastic surgery. We used a prospective, non-randomized, pre-post trial in video assisted thoracic surgery (VATS) lobectomy, total laparoscopic hysterectomy, laparoscopic low anterior resection, and deep inferior epigastric perforator (DIEP) flap breast reconstruction. Overall, 775 cases performed between February 2021 and August 2023 were included in the study, 521 for VATS lobectomy (control n = 164), 127 for laparoscopic total hysterectomy (control n = 19), 48 for laparoscopic colorectal surgery (control n = 8), and 79 for DIEP flap breast reconstruction (control n = 53). Average age was 63 years with 67% female and average BMI of 27.57 kg/m