Nurse burnout remains a significant problem affecting the nursing workforce today. However, despite calls for changes that could reduce clinician administrative burdens due to their relationship with burnout, minimal opportunities for improvement have been identified. Therefore, the purpose of this study was to investigate the relationship between nurse burnout and nurse satisfaction with the electronic health record (EHR). A cross-sectional survey was administered in 2018 to nurses practicing in the state of Alabama in the United States (N = 950). The survey inquired about participants' burnout, EHR satisfaction, and the nurse work environment. In multiple regression models, years of experience, nurse satisfaction with the EHR, and the nurse work environment explained 20%-34% of the variation in nurses' work-related burnout. Although additional research is needed, the EHR may be one actionable area that organizations could modify to help reduce nurse burnout.