OBJECTIVES: To determine acceptance of potential risks in orthodontic treatment and whether it could be affected by personality traits of patients. MATERIALS AND METHODS: Two hundred sixty-one adult participants consulting for orthodontic treatment were involved in this cross-sectional study. Acceptance of 18 orthodontic risks was investigated with a structured questionnaire. Personality traits of included patients were assessed with a validated Chinese version of the Big Five Inventory. Statistical analyses were performed as appropriate, and potential correlations were identified using multivariate binary logistic regression analysis. RESULTS: Acceptability of the investigated orthodontic risks ranged from 47.1% to 87.0%, with periodontitis being the least accepted. Length of treatment (P = .015) and relapse (P = .007) were more unacceptable to older patients. Female participants showed less tolerance to periodontitis (P = .017) than male counterparts. Among the five dimensions of personality traits, conscientiousness was significantly associated with acceptance of tooth extraction and associated risks (odds ratio [OR] = 1.131, P = .002), problems eating (OR = 1.182, P <
.001), problems speaking (OR = 1.111, P = .022), and appliance breakage (OR = 1.109, P = .008), while openness was a significant predictor to the acceptance of length of treatment (OR = 1.090, P = .044). CONCLUSIONS: Among patients seeking orthodontic treatment, periodontitis was the least accepted risk. A significant association was found between the acceptance of certain orthodontic risks and personality traits, especially conscientiousness and openness.