Sports-related injuries are costly to treat and have many associated intangible effects. Musculoskeletal health care professionals in rehabilitation strive to keep athletes at their peak performance with a principal focus on injury prevention. "Prevention is better than a cure" remains relevant to all athletes and non-athletes alike. In this special issue of Arthroscopy, Sports Medicine, and Rehabilitation, "Injury Prevention and Rehabilitation," we bring a multifaceted approach and diverse perspectives in helping athletes and active individuals remain injury free with prevention and training strategies, while optimizing performance and providing key rehabilitation strategies for common sports-related injuries.