Maternal depressive symptoms in childhood and offspring brain cortical and subcortical volumetric change: A repeated imaging study from age 4-10 years.

• Tác giả: Birit Broekman, Helen Chen, Peter Gluckman, Yuna Koyama, Ekaterina Sadikova, Peipei Setoh, Ai Peng Tan, Henning Tiemeier, Juan Helen Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 784.1887 General principles, musical forms, instruments
• Thông tin xuất bản: Netherlands : Developmental cognitive neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 182828

Tóm tắt

 Maternal depressive symptoms have been associated with offspring's brain structural differences. However, previous studies were limited by cross-sectional designs, brain region-of-interest analyses, or clinical samples. Importantly, few studies assessed the early childhood brain. This study analyzed data from a Singaporean cohort of 217 children with 589 repeated structural neuroimaging from 4.5 to 10.5 years (2-4 assessments) in relation to maternal depressive symptoms. Maternal depressive symptoms were measured by questionnaire at child age 4.5 years. Mixed models explored within-sample change accounting for non-linear brain development. Multiple testing was corrected, and a stringent threshold was applied. Maternal depressive symptoms were associated with persistently smaller precentral gyral volume over time (β = -0.162 [-0.238
  -0.086], p