Lipophilic antioxidants (LAOs) are essential for physical and mental health of all mammals. Their importance in the treatment and prevention of diseases is undeniable. Alongside water-soluble antioxidants, LAOs play a crucial role in maintaining the quality and stability of various food, cosmetic, and pharmaceutical products. Electrochemical detection methods have emerged as powerful analytical tools for identifying and quantifying a broad range of analytes. However, LAOs are often overlooked targets for electrochemical analysis. This critical review aims to explore the current advancements, limitations, and future perspectives of electrochemical detection methods for LAOs. The observed electrochemical methods in LAOs investigations are: cyclic voltammetry, differential pulse voltammetry, square wave voltammetry, electrochemical impedance spectroscopy, and square wave anodic stripping voltammetry. Additionally, electrochemical evaluation of total antioxidant capacity and activity are included for the discussions. The review provides an overview of the electrochemical (bio)sensors from 2018 to 2024 for LAOs determination of following groups: synthetic (phenolic, amine and organophosphate antioxidants), and natural (tocopherols, carotenoids, polyunsaturated fatty acids) antioxidants, including vitamins D and K, coenzyme Q, which are not directly associated to the antioxidant group, but also possess antioxidant activity. The general preferences of medium selection and practical aspects of the sample preparation strategy are included.