Empirical dosage determination of vancomycin for a target area under the concentration-time curve of 400 μg·h/mL in the first 24 h: A prospective multicenter observational study with rich sampling.

• Tác giả: Hirokazu Furusho, Yoko Hiyama, Takeshi Ide, Sachiko Jingami, Hirofumi Jono, Tomomi Katanoda, Yusuke Kusaka, Kazutaka Oda, Hideyuki Saito, Takashi Tomita, Takashi Ueda, Tomoyuki Yamada, Hiroshi Yoshikawa
• Ngôn ngữ: eng
• Ký hiệu phân loại: 171.8 Systems based on altruism
• Thông tin xuất bản: England : British journal of clinical pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 183051

Tóm tắt

AIM: Area under the concentration-time curve (AUC)-guided dosing is recommended in vancomycin therapy. This study aims to determine the empirical dosing for achieving an AUC on the first day (AUC METHODS: A multicentric prospective study was conducted across five hospitals. Critically ill patients were included, with rich sampling conducted on the first day and/or days 3-5 of therapy. Cumulative dose on the first day for the trapezoidal AUC RESULTS: The study included 27 patients and 395 samplings were performed. The mean cumulative dose (standard deviation) on the first day was higher in the group with AUC CONCLUSION: This study suggested an empirical dosage of about 50 mg/kg on the first day of vancomycin therapy and the use of two-point sampling in Bayesian estimations to enhance accuracy. TRIAL REGISTRATION: Not applicable because this is a non-intervention study.