UPF 648, a Selective KMO Inhibitor, Attenuates Psychomotor and Cognitive Impairment in Chronic Kidney Disease.

• Tác giả: Aparajita Ghosh, Abhijeet R Joshi, Onkar P Kulkarni, Neeraja Rayanki
• Ngôn ngữ: eng
• Ký hiệu phân loại: 238.14 Nicene and post-Nicene creeds of Western Church
• Thông tin xuất bản: United States : ACS chemical neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 183157

Tóm tắt

Kynurenine-3-monooxygenase (KMO), a key enzyme in the kynurenine pathway (KP) of tryptophan metabolism, converts kynurenine into the neurotoxic intermediate quinolinic acid (QA). QA, an