Are All Pharmacokinetic Equations Created Equal? A Comparative Analysis of Trapezoidal and Non-Trapezoidal Methods for Estimating Day 1 Area Under the Curve in Adult Hospitalized Patients with Staphylococcus aureus Bacteremia.

• Tác giả: Jacinda C Abdul-Mutakabbir, Abdulwhab Shremo Msdi, Alireza Fakhri Ravari, Karen K Tan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 579.353 *Staphylococcus
• Thông tin xuất bản: New Zealand : Infectious diseases and therapy , 2025
• Bộ sưu tập: NCBI
• ID: 183936

Tóm tắt

INTRODUCTION: This study compared the calculated vancomycin area under the curve (AUC METHODS: This retrospective observational study included adult patients with documented MRSA bacteremia who received ≥ 48 h of intravenous vancomycin and had two consecutive serum levels after the first dose. AUC RESULTS: Fifty-two patients were included. The median age was 63 years (interquartile range [IQR]: 50-73), and the median vancomycin clearance was 4 l/h (IQR: 2-6). Median vancomycin AUC CONCLUSIONS: Trapezoidal and non-trapezoidal equations are not interchangeable for estimating vancomycin AUC