Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke.

• Tác giả: Louis-Philippe Bernier, Murphy DeMeglio, Lasse Dissing-Olesen, David Guo, Jasmin K Hefendehl, Jan Hofmann, Coral-Ann Lewis, Brian A MacVicar, Fabio M Rossi, R Wilder Scott, Stefan Simm, Hesham Soliman, Lin Wei Tung, T Michael Underhill
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Nature neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 184155

Tóm tắt

Functional revascularization is key to stroke recovery and requires remodeling and regeneration of blood vessels around which is located the brain's only stromal compartment. Stromal progenitor cells (SPCs) are critical for tissue regeneration following injury in many organs, yet their identity in the brain remains elusive. Here we show that the perivascular niche of brain SPCs includes pericytes, venular smooth muscle cells and perivascular fibroblasts that together help cerebral microvasculature regenerate following experimental stroke. Ischemic injury triggers amplification of pericytes and perivascular fibroblasts in the infarct region where they associate with endothelial cells inside a reactive astrocyte border. Fate-tracking of Hic1