Krüppel-like factor 9 alleviates Alzheimer's disease via IDE-mediated Aβ degradation.

• Tác giả: Yong-Sheng Chang, Chun-Yuan Du, Yue-Yao Feng, Jing-Ran Hao, Zhe Pan, Wei Qiao, Ping Qiu, Tong-Tong Qiu, Jin-Jin Wu, Chao-Fan Xu, Meng-Lin Zhang, Yin-Liang Zhang, Yu-Jie Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: United States : Acta pharmacologica Sinica , 2025
• Bộ sưu tập: NCBI
• ID: 184188

Tóm tắt

The deposition of β-amyloid (Aβ) in the brain is a crucial factor in the pathogenesis of Alzheimer's disease (AD). Insulin-degrading enzyme (IDE) plays a critical role in the balance between Aβ production and degradation. However, the regulatory mechanisms of IDE are not yet fully understood. Therefore, uncovering additional IDE regulatory mechanisms will help elucidate the pathogenesis of AD and identify key therapeutic targets for this disease. This study revealed that global Krüppel-like factor 9-mutant (Klf9