BACKGROUND: Medical fraud and abuse represent significant global challenges in healthcare systems, resulting in financial losses estimated at 3% to 15% of total healthcare expenditures annually. These practices compromise both the cost-efficiency and quality of care delivery. The aim of this study is to provide a comprehensive scoping review of the patterns and strategies for combating medical fraud and abuse, with a focus on prevention, detection, and legal responses. METHODS: The review followed Arksey and O'Malley's five-step framework for scoping reviews. A systematic search was conducted using keywords such as "fraud," "abuse," and "health insurance" in databases including Medline, Scopus, Elsevier, PubMed, BMJ, and ScienceDirect. The search spanned literature published between 2000 and 2024. Additional sources, such as organizational websites of healthcare fraud associations, were consulted. Studies were selected based on inclusion criteria emphasizing definitions, detection, prevention, and management methods related to healthcare fraud. A total of 31 studies were ultimately included. RESULTS: The findings highlight the multifaceted nature of healthcare fraud and abuse, involving various actors such as healthcare providers, patients, and insurers. Key methods for detecting fraud include advanced data-driven techniques like machine learning, data mining, and predictive analytics, which were predominantly employed in high-income countries. Traditional methods, such as manual audits and inspections, remain common in low- and middle-income countries (LMICs) but are less effective due to resource limitations. Preventive strategies include ethical training for healthcare providers, patient education, implementation of strict recruitment policies, and the establishment of robust internal controls. Legal responses, such as punitive measures, inter-agency collaboration, and incentive-based programs, were identified as essential components of a comprehensive fraud management strategy. A regional disparity in detection and prevention methods underscores the need for context-specific strategies tailored to the infrastructure and regulatory environments of different countries. DISCUSSION: High-income countries, such as the United States and European nations, leverage advanced detection technologies and strict legal frameworks, which have proven effective in mitigating healthcare fraud. In contrast, LMICs often rely on traditional methods and informal deterrents due to technological and regulatory constraints. The findings suggest that integrating digital solutions, such as electronic health records and centralized data systems, could enhance fraud detection in resource-limited settings. Additionally, the importance of ethical training, cultural shifts, and patient empowerment in preventing fraud was emphasized. Collaboration between healthcare providers, insurers, and regulatory agencies emerged as a critical factor for effective fraud management. CONCLUSION: Addressing medical fraud and abuse requires a multi-pronged approach combining prevention, detection, and legal responses. Advanced technologies, ethical reforms, and robust legal frameworks are pivotal in building transparent and trustworthy healthcare systems. Policymakers, particularly in LMICs, should prioritize capacity-building initiatives, international collaborations, and the adoption of cost-effective technological solutions. Future research should explore the long-term impacts of incentive-based programs and legal enforcement on fraud reduction, with a focus on tailoring interventions to specific healthcare system vulnerabilities. IMPLICATIONS: This study provides actionable insights for healthcare administrators and policymakers seeking to develop targeted strategies to combat fraud and abuse. It underscores the necessity of balancing technology-driven solutions with ethical and regulatory reforms to create a holistic and sustainable approach to fraud management globally.