Capacitance Effects of Nanopore Chips on Ionic Current Modulation and Noise Characteristics.

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Tác giả: Chen Chen, Dongxuan Li, Haoyong Li, Kabin Lin, Jinzhu Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 627.12 Rivers and streams

Thông tin xuất bản: England : Nanotechnology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 185033

Solid-state nanopores exhibit adjustable pore size, robust chemical and thermal stability, and compatibility with semiconductor fabrication, positioning them as versatile platforms for nanofluidic applications and single-molecule detection. However, their higher noise levels compared to biological nanopores hinder their sensitivity in detecting biomolecules such as DNA and proteins. Enhancing detection sensitivity requires an in-depth understanding of noise sources and strategies for noise reduction. Here, we construct an equivalent circuit model of solid-state nanopores and conduct corresponding experiments to evaluate how chip capacitance, salt concentration, applied voltage, and pore size influence ionic current noise. We find that chip capacitance is the dominant factor affecting ionic current noise, with minimal noise sensitivity to salt concentration below 0.1 M but pronounced increases above this threshold. The pH has little impact on noise, whereas higher applied voltages elevate noise at high salt concentrations. Introducing a SiO
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