OBJECTIVE: To observe the effect of cluster nursing based on multidisciplinary management strategy in perioperative venous thromboembolism (VTE) prevention and control in gastrointestinal cancer patients. METHODS: A total of 263 gastrointestinal cancer patients admitted to our hospital between January 2022 and September 2023 were included in the study. The patients were stratified into a control group (n=118) and a quality improvement group (n=145). Routine nursing care was administered to the control group, while the quality improvement group received cluster nursing based on multidisciplinary management strategy. RESULTS: The total incidence of VTE in the quality improvement group (11.7%) was significantly lower compared to the control group (26.3%). The correct rate of VTE assessment by nurses in the quality improvement group stood at 80.0%, significantly surpassing the control group rate of 61.0% (p <
0.001). The timeliness rates of VTE assessment within 24 hours of admission, before, and after surgery were 91.7%, 95.2%, and 95.9%, respectively, in the quality improvement group, as opposed to 89.8%, 86.4%, and 87.3% in the control group, indicating a significant improvement in timeliness rates before and after surgery (all p <
0.05). The quality improvement group demonstrated a significant increase in both the implementation rate of health education and VTE preventive measures (all p <
0.05). CONCLUSION: Cluster nursing based on multidisciplinary management strategy has the potential to significantly decrease the incidence of perioperative VTE in patients with gastrointestinal cancer and improve awareness of VTE prevention and treatment among both medical professionals and patients.