BACKGROUND: One of the most researched issues is the elimination of uremic toxins from the human body. These toxins can build up and lead to catastrophic issues including renal failure. To get rid of them, absorbents like activated carbon, zeolites, and other minerals are frequently utilized. METHODS: Mesoporous silica nanoparticles functionalized with (3-Aminopropyl) triethoxysilane (APTES) linker (MSN-NH RESULTS: MSN-MIP's large surface area (879.12 (m CONCLUSION: Synthesized adsorbents can be utilized in the hemodialysis system since the results of the cell viability test also showed that the percentage of cell viability was extremely high up to 72 hours.