Ru(II)-Fenamic-Based Complexes as Promising Human Ovarian Antitumor Agents: DNA Interaction, Cellular Uptake, and Three-Dimensional Spheroid Models.

• Tác giả: Wladimir Badaró, Alzir A Batista, Rodrigo S Correa, Rayane C Costa, Javier Ellena, José A Gomes Neto, Pedro Henrique Machado, Carlos A F Moraes, Marcos V Palmeira-Mello, Camila Pinto, Tamara Teixeira, Fillipe Vieira Rocha
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Inorganic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 185789

Tóm tắt

Cancer resistance to chemotherapeutic agents such as cisplatin presents a significant challenge, leading to treatment failure and poor outcomes. Novel metal-based compounds offer a promising strategy to overcome drug resistance and to enhance efficacy. Four Ru(II) complexes with fenamic acid derivatives were synthesized and characterized: [Ru(L)(bipy)(dppp)]PF