AIM: To develop a glycerol modified liposomes to effectively deliver active agents into posterior segment of the eye for the management of posterior uveitis. MATERIALS AND METHODS: The modified liposome enhanced with glycerol as an edge activator was fabricated using a 3 RESULTS AND CONCLUSIONS: Nano-vesicles resulted in size and deformability index of 200.5 ± 15 nm and 11.58, respectively, with entrapment efficiency of 80.98% of the drug. Moreover, the optimized lenses demonstrated 71%) of swelling and transmittance of 87%). In addition,