Chiral Phosphoric Acid-Catalyzed Hydrolytic Parallel Kinetic Resolution of Racemic Epoxides and Activated Alcohols.

• Tác giả: Yi-Ming Cao, Yi-Ying Du, Long-Hui Gai, Yu-Shi He, Yan Liang, Juan Liu, Shang-Zhong Liu, Xue-Song Liu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 633.89 Crops grown for other industrial purposes
• Thông tin xuất bản: United States : Organic letters , 2025
• Bộ sưu tập: NCBI
• ID: 186508

Tóm tắt

We report a chiral phosphoric acid-catalyzed hydrolytic parallel kinetic resolution (HPKR) of racemic epoxides and activated alcohols. Using an acyloxy-assisted activation strategy, this method enables the highly stereocontrolled hydrolysis under mild conditions. A wide range of aryl-substituted epoxides and activated secondary alcohols were effectively transformed, providing corresponding chiral alcohols with combined yields of up to 99% and enantiomeric ratios exceeding 99:1.