An attenuated African swine fever virus expressing the E2 glycoprotein of classical swine fever virus protects pigs against challenge of both viruses.

• Tác giả: Zhigao Bu, Weiye Chen, Ronghong Hua, Fang Li, Yongfeng Li, Renqiang Liu, Huaji Qiu, Encheng Sun, Jiwen Zhang, Zhenjiang Zhang, Dongming Zhao, Yuanmao Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.502 Middle Byzantine period, 717–1081
• Thông tin xuất bản: United States : Emerging microbes & infections , 2025
• Bộ sưu tập: NCBI
• ID: 186595

Tóm tắt

African swine fever (ASF) and classical swine fever (CSF) are highly contagious diseases with high morbidity and mortality rates resulting in an enormous impact on the global pig industry. A bivalent vaccine that simultaneously protects against both ASF and CSF is highly desirable. We previously developed a seven-gene-deleted African swine fever virus (ASFV) attenuated vaccine candidate (HLJ/18-7GD) that provides complete protection against homologous strains. Herein, we constructed a recombinant virus HLJ/18-7GD-E2 by inserting the classical swine fever virus (CSFV) E2 gene into the HLJ/18-7GD via homologous recombination. After continuous