Gene regulatory network resource aids in predicting trans-acting regulators of biosynthetic gene clusters in

• Tác giả: Jin Woo Bok, Nancy P Keller, Hye-Won Seo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 305.568 +Alienated and excluded classes
• Thông tin xuất bản: United States : mBio , 2025
• Bộ sưu tập: NCBI
• ID: 186731

Tóm tắt

The field of secondary metabolism has greatly benefitted from computational advances in recent years. This has been particularly true for fungal natural product studies. Strides in genome mining have led to the identification of an extraordinary number of secondary metabolite biosynthetic gene clusters (BGCs) across the fungal Kingdom and metabologenomic platforms can group BGCs into gene cluster families and link them to initial chemical structures. Missing are computational applications focused on identifying BGC regulatory networks. Here, we applied the new online gene regulatory network resource, GRAsp (