Hydrotalcites-Induced Pyroptosis Combined with Toll-Like Receptor Activation Elicited Dual Stimulation of Innate and Adaptive Immunity.

• Tác giả: Jie Cao, Chong Cheng, Liang Cheng, Xiaoliang Cui, Zhihui Han, Yechen Huang, Zhicheng Liu, Xiaoxiao Pan, Zifan Pei, Shumin Sun, Jianman Wang, Li Wang, Jie Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 627.12 Rivers and streams
• Thông tin xuất bản: United States : ACS nano , 2025
• Bộ sưu tập: NCBI
• ID: 186810

Tóm tắt

Increasing evidence illustrates the significance of promoting tumor immunogenicity and an efficient immune response in immunotherapy, but the immunosuppressive tumor microenvironment (TME) remains an obstacle. Herein, AlZn hydrotalcite (AZOH) was synthesized as a pyroptosis inducer and further loaded with R848 to formulate R@AZOH. R@AZOH efficiently triggered CT26 cell pyroptosis through Zn