Nmnat2 deficiency in the arcuate nucleus or paraventricular nucleus induces Sarm1-independent neuron loss and liraglutide-reversible obesity.

• Tác giả: Yalan Cheng, Jieya Dong, Ning Feng, Peidong Gao, Yumo Han, Zhishui He, Rui Huang, Hejin Lai, Zongyang Liu, Ziru Shen, Yingqi Wang, Huimin Yu, Qiwei Zhai, Cong Zhang, Zhentong Zhang, Wuling Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 571.66 +Nucleus
• Thông tin xuất bản: United States : FASEB journal : official publication of the Federation of American Societies for Experimental Biology , 2025
• Bộ sưu tập: NCBI
• ID: 186844

Tóm tắt

Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) plays an important role in maintaining axon integrity, and the arcuate nucleus (ARC), and paraventricular nucleus (PVN) are crucial nuclei in the control of energy balance. However, the effect of Nmnat2 deficiency in ARC and PVN is still unclear. Nmnat2