Drag reduction is crucial for many industries, ranging from aerospace to microfluidics, to enhance the energy efficiency and reduce costs. This work is the first to study drag reduction enabled by novel slippery liquid-like surfaces fabricated from flexible polymers. We experimentally characterized the drag reduction performance of slippery liquid-like surfaces in the laminar flow regime. Our results indicate that liquid-like surfaces can reduce fluid drag regardless of surface wettability and have achieved nearly 20% drag reduction. Furthermore, the durability tests show that these surfaces can maintain slipperiness over a month when exposed to air or water and the drag reduction capability for at least one week under a fluid flow. These findings highlight the potential of slippery liquid-like surfaces as a promising solution for sustainable drag reduction.