Shortened Relative Leukocyte Telomere Length Is Associated With Polycystic Ovary Syndrome and Metabolic Traits.

• Tác giả: Juliana C N Chan, Raymond N C Chan, Feifei Cheng, Lai Ping Cheung, Anandwardhan A Hardikar, Chuiguo Huang, Alicia J Jenkins, Mugdha V Joglekar, Cadmon K P Lim, Ronald C W Ma, Alex C W Ng, Noel Y H Ng, Mai Shi, Claudia H T Tam, Henry C H Tam, Wing Hung Tam, Atta Y T Tsang, Chi Chiu Wang, Kwun Kiu Wong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.858841 Diseases of nervous system and mental disorders
• Thông tin xuất bản: England : Endocrinology, diabetes & metabolism , 2025
• Bộ sưu tập: NCBI
• ID: 187118

Tóm tắt

 BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the commonest gyneco-endocrine disorders amongst women of reproductive age. Whether PCOS and cardiometabolic traits in PCOS patients are associated with shortened telomere length (TL) or relative leukocyte telomere length (rLTL) remains unclear. METHODS: 214 women with PCOS and 214 age-matched women were recruited. rLTL was measured with an updated quantitative real-time PCR protocol and reported as ΔΔCt between telomere and a single-copy gene encoding β-globin relative to a normalisation control. A two-way Mendelian randomization analysis using the UK Biobank Resource was performed to assess the causal relationship between rLTL and PCOS. RESULTS: Women with PCOS had significantly shortened rLTL (PCOS: 0.5 ± 0.7
  control: 0.8 ± 0.6
  p <
  0.001). Longer rLTL was associated with a lower risk of PCOS after adjusting for age, history of smoking and other cardiometabolic traits (OR: 0.503
  95% CI: 0.342-0.730
  p <
  0.001). Longer rLTL was associated with reduced risk of dyslidpidemia (OR: 0.563
  95% CI: 0.450-0.968
  p = 0.042) in PCOS patients. PCOS subjects with rLTL shorter than mean of the rLTL of control subjects had an elevated risk of dysglycemia (OR: 2.09
  95% CI: 1.04-4.29
  p = 0.040). No causal relationships were found between rLTL and PCOS in the Mendelian randomization study. CONCLUSIONS: Women with PCOS have significantly reduced rLTL and shorter LTL may be associated with cardiometabolic risk factors in PCOS subjects. There are no causal relationship between genetically determined PCOS and TL or vice versa.