Box-Behnken Design and Molecular Docking Assisted Quenching Spectrofluorimetric Method for the Quantitation of Citalopram HBr in Commercial Dosage Forms.

• Tác giả: Qamar Uddin Ahmed, Al Anood Ahmed Abdullah Al Farsi, Mahboob Alam, Syed Najmul Hejaz Azmi, Md Abdur Rashid Mia, Zamzam Sulaiman Zahran Al Nabhani, Nafisur Rahman, Wafa Aqib Nasir Al Rawahi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 781.726 *Holy Week
• Thông tin xuất bản: Netherlands : Journal of fluorescence , 2025
• Bộ sưu tập: NCBI
• ID: 187456

Tóm tắt

A simple, sensitive and accurate spectrofluorimetric method was presented for the determination of citalopram hydrobromide (CTM) in tablets. The method was based on the quenching of bovine serum albumin (BSA) fluorescence with CTM at pH 7.4. The fluorescence intensities were measured at 342 nm after excitation at 279 nm. Various factors affecting the quenching of BSA fluorescence were optimized by response surface methodology (RSM) through Box-Behnken design (BBD. The plot of F