The proliferation of novel technologies like virtual reality, health monitoring has sparked a surge in demand for wearable devices, electronic skin, and other cutting-edge technologies. Flexible pressure sensors serve as essential components that have attracted considerable interest. Most current flexible pressure sensors require external power sources and have complex structures, presenting obstacles when utilized on the surface of the human body. This study introduces a flexible pressure sensor based on electrospinning and electrochemical reactions, which does not require external power source while demonstrating excellent sensing capabilities. It is important to note that the sensor, owing to the fully spun fabrication process, demonstrates superior breathability compared to cotton fabrics. The sensor sensitivity can reach up to 143 mV/kPa, with a wide operating range of 0 to 400 kPa, it exhibits remarkable recognition capabilities for both static and dynamic forces. Additionally, the sensor features a short response time of 50 ms for the rising edge and 40 ms for the falling edge, allowing it to accurately detect the pressure applied under repeated stimuli ranging from 1 to 8 Hz. Furthermore, efforts have been made to employ the sensor in the development of a human motion and health monitoring system, further exploring its potential within the application of electronic skin technology. This research introduces a novel perspective for the advancement of future intelligent devices.