A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection.

• Tác giả: Qiyao Chai, Yingxu Fang, Pupu Ge, Zehui Lei, Bingxi Li, Cui Hua Liu, Zhe Lu, Lihua Qiang, Jing Wang, Yong Zhang, Mengyuan Zhao, Yanzhao Zhong
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 187605

Tóm tắt

Crosstalk between cell death programs confers appropriate host anti-infection immune responses, but how pathogens co-opt host molecular switches of cell death pathways to reprogram cell death modalities for facilitating infection remains largely unexplored. Here, we identify mammalian cell entry 3C (Mce3C) as a pathogenic cell death regulator secreted by