Bioavailability and dose proportionality of a highly lipophilic phenolic antioxidant.

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Tác giả: Galina A Chernysheva, Galina A Frelikh, Alexander P Lakeev, Vera I Smolyakova, Elena A Yanovskaya

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : Xenobiotica; the fate of foreign compounds in biological systems , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 187612

IBP (2,6-diisobornyl-4-methylphenol) is a camphene derivative with unique pharmacological properties and low toxicity. It exhibits pronounced antioxidant and membrane-protective effects, making it a promising cardio- and neuroprotector.The aim of the study was investigating the pharmacokinetics of IBP in rats after intravenous (1 mg/kg) and oral administration at three doses (10, 25, 50 mg/kg). Specifically, we focused on assessing the bioavailability and dose proportionality following oral administration.Blood samples were collected via a jugular vein catheter, and plasma samples were analyzed using a validated HPLC-MS/MS method. The calculation of pharmacokinetic parameters was performed by both non-compartmental and compartmental approaches. The proposed dosage form for intravenous administration was a multicomponent mixture containing
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