Societal restrictions impact transgender individuals' ability to engage in occupations that match their internal gender identity preventing gender affirmation. The aim was to explore transgender individuals' perceived levels of gender congruence and life satisfaction. A cross-sectional survey with a nonprobability sample of transgender adults was used to provide a preliminary exploration of transgender individuals' gender congruence and life satisfaction using the Gender Congruence and Life Satisfaction and World Health Organization Quality of Life-BREF. When comparing the means of the physical, psychological, social, and environmental domains to the population norm, the respondents demonstrated statistically lower scores in all four domains of the WHOQOL-BREF. In both the WHOQOL-BREF and GCLS, the mean score in psychological health and life satisfaction were the lowest. Transgender individuals prioritize self-care activities, such as hairstyling, and body image to affirm internal gender identity. Occupational therapy can assist with supporting gender transition in several occupational contexts.